Cardiff Oncology Reports Results of Onvansertib in P-Ib/II Trial for the Treatment of KRAS-Mutated Metastatic Colorectal Cancer
Shots:
- The P-Ib/II trial evaluates the safety and preliminary efficacy of onvansertib + Folfiri and Avastin in 2L treatment of patients with KRAS-mutated mCRC
- As of July 2- 2021- 42% patients achieved a partial response at RP2D (15 mg/m2 dose); confirmed PR (37%); ORR (5-13%); mPFS has not yet reached. Additionally- 38% patients achieved an initial PR who treated at all dose levels (12 mg/m2- 15 mg/m2- 18 mg/m2); confirmed PR (31%); mPFS (9.4mos.) across all response-evaluable patients
- Additionally- partial responses were observed across different KRAS mutation variants. The combination is well-tolerated and showed the synergistic effect
| Ref: Cardiff Oncology | Image: PharmaLive
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